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Abrams, Elizabeth T.

Grant Type: 
Dissertation Fieldwork Grant
Insitutional Affiliation: 
Michigan, Ann Arbor, U. of
Completed Grant
Approve Date: 
September 13, 2001
Project Title: 
Abrams, Elizabeth T., U. of Michigan, Ann Arbor, MI - To aid research on 'Variability in Birth Outcome following Malaria during Pregnancy,' supervised by Dr. A. Roberto Frisancho

ELIZABETH T. ABRAMS, while a student at the University of Michigan in Ann Arbor, Michigan, was awarded a grant in September 2001 to aid research on variability in birth outcomes following malaria during pregnancy, under the supervision of Dr. A. Roberto Frisancho. Malaria infections during pregnancy are associated with a number of poor birth outcomes, including intrauterine growth retardation, preterm delivery, and fetal death. Previous researchers had identified malaria-induced immune responses and birth outcomes, but the immune response to malaria could not fully account for the variation in birth outcomes. Abrams focused on a second potential determinant of poor birth outcomes: maternal and fetal iron status. She examined umbilical-cord hemoglobin levels in 33 malaria-infected and 57 uninfected women delivering in Blantyre, Malawi, in relation to maternal hemoglobin levels, malaria status, neonatal inflammation, and birth outcome. Although, as expected, maternal hemoglobin levels were significantly decreased by malaria infection during pregnancy, there was no reduction in cord levels, nor was there any significant relationship between the two. Nevertheless, cord ferritin levels were elevated in the neonates of malaria-infected mothers in relation to increased parasitemia, suggesting fetal immune activation to maternal malaria. Increased cord ferritin was associated with significantly d