George, Ian Douglas, U. of Missouri, Columbia, MO - To aid research on 'Mapping the Cerebrocerebellar Language Network and its Role in Human Neuroevolution,' supervised by Dr. Kristina Aldridge
Preliminary abstract: Language is arguably the key factor that has influenced the evolution of the human brain. It is likely that increased language capabilities in humans are associated with both gross morphological changes as well as with novel neural networks. Endocasts, our only direct evidence of the brains of human ancestors, have revealed a disproportionate increase in size of the cerebellum relative to the cerebrum. Moreover, it is thought the cerebellum plays an important role in modulating language production through neural networks with the cerebellum. This project seeks to map the connectivity between the cerebrum and cerebellum and establish the pattern of the language-specific cerebrocerebellar network (LSCN) in the adult human brain thought the use cutting-edge in vivo quantitative imaging techniques. The proposed research will be the first to verify that the cerebellum is a key component of the language network in the brain. In addition, the proposed research will provide critical data on how much can be known about language from the study of fossil brain endocasts by testing the assumption that surface morphology reflects the architecture of underlying brain structure, enabling us to test the hypotheses that make predictions about the behavior of fossil hominin ancestors from endocast data.
Kuzawa, Dr. Christopher, Northwestern U., Evanston, IL - To aid research on 'Developmental Plasticity of Male Reproductive Ecology and Life History'
DR. CHRISTOPHER KUZAWA, Northwestern University, Evanston, Illinois, received funding in December 2005 to aid research on 'Developmental Plasticity of Male Reproductive Ecology and Life History.' Dr. Kuzawa and an international team from Northwestern University, the University of North Carolina (Chapel Hill), and the University of San Carlos (the Philippines), investigated whether fetal and infant nutrition and growth influence male reproductive biology (morning and evening salivary testosterone; luteinizing hormone measured in blood samples). They hypothesized that birth weight or length (measures of prenatal nutrition) and/or growth rate or diarrheal morbidity during infancy (postnatal nutrition) would predict adult testosterone levels. Participants included roughly 900 young adults in a long-term study of health in the Philippines. In this population, males born tall and skinny had highest T levels as adults. During infancy, how often an individual experienced the nutritional-stress of diarrhea predicted future T levels: the more nutritional stress early in life, the lower the production of T in adulthood. Similarly, weight gain during infancy, an indirect measure of nutritional sufficiency, was a strong positive predictor of adult T levels. These responses likely involve changes in regulation by the brain and also in testicular development. This study is significant as it is among the first to demonstrate how early life nutrition can have a lasting influence on the reproductive ecology of the adult male.
Piperata, Barbara A., U. of Colorado, Boulder, CO - To aid research on 'The Energetics of Lactation among Tropical Horticulturists Living in the Brazilian Amazon,' supervised by Dr. Darna L. Dufour
BARBARA A. PIPERATA, while a student at the University of Colorado in Boulder, Colorado, received funding in January 2002 to aid research on the energetics of lactation among tropical horticulturists in the Brazilian Amazon, under the supervision of Dr. Darna L. Dufour. Piperata's goal was to understand how tropical horticultural women met the increased energetic demands of lactation when they lived in conditions of food scarcity and practiced subsistence agriculture. She followed twenty-three women over their first six months of lactation and took measurements of their dietary intake, energy expenditure, and body composition at three times (forty days, two to four months, and six months postpartum) in order to identify the strategies used to meet the increased energy demands of lactation. One of the most interesting adaptive strategies these women used was the cultural practice called resguardo. During this forty-day immediate postpartum period, the women were excused from all strenuous work, including subsistence activities, and depended on other household members, especially husbands, to meet subsistence demands. By two to four months postpartum, women had returned to more normal activity patterns, and body fat stores became important for meeting energy needs. By six months postpartum, all women were supplementing their infants' diets, but most women continued to lose weight, indicating that their food intake was insufficient to meet their caloric needs. Thus, the strategies utilized by these women changed over the course of lactation. These findings illustrate the importance of an in-depth, longitudinal, biocultural approach to studying a life-history event such as lactation.
Piperata, Barbara A., and Lindsey M. Gooden Mattern. 2011. Longitudinal Study of Breastfeedng Structure and Women's Work in the Brazilian Amazon. American Journal of Physical Anthropology 144(2):226-237
Piperata, Barbara A. 2007. Nutritional Status of Ribeirinhos in Brazil and the Nutrition Transition. American Journal of Physical Anthropology 133(2):868-787.
Piperata, Barbara. 2004. Rural-to-Urban Migration in Latin America: An Update and Thoughts on the Model. American Journal of Human Biology 16:395-404
Piperata, Barbara. 2007. Diet, Energy Expenditure, and Body Composition of Lactating Ribeirinha Women in the Brazilian Amazon. American Journal of Human Biology 19:722-734
Piperata, Barbara. 2007. Nutritional Status of Ribeirinhos in Brazil and the Nutrition Transition. American Journal of Physical Anthropology 133:868-878
Vercellotti, Guiuseppe, Barbara A. Piperata, Amanda M. Agnew, et al. 2014. Exploring the Multidimensionality of Stature Variation in the Past through Comparisons of Archaeological and Living Populations. American Journal of Physical Anthropology 155(2): 229-242.
Vercellotti, Giuseppe, and Barbara A. Piperata. 2012. The Use of Biocultural Data in Interpreting Sex Differences in Body Proportions among Rural Amazonians. American Journal of Physical Anthropology 147(1):113-127.
Young, Bonnie Nadyne, U. of New Mexico, Albuquerque, NM - To aid research on 'Effects of Genetic Ancestry and Socio-Cultural Factors on Susceptibility to Tuberculosis in Mexico,' supervised by Dr. Keith L. Hunley
BONNIE N. YOUNG, then a student at the University of New Mexico, Albuquerque, New Mexico, received funding in October 2009, to aid research on 'Effects of Genetic Ancestry and Socio-Cultural Factors on Susceptibility to Tuberculosis in Mexico,' Supervised by Dr. Keith L. Hunley. Active tuberculosis (TB) varies substantially across regions and ethnic groups due to different genetic and environmental factors. Less TB among those with high European ancestry suggest better socioeconomic conditions and possibly innate resistance, although the impact of ancestry remains unresolved. This study assesses the effect of genetic ancestry on active TB, and the interactions between ancestry and contextual factors. Fieldwork occurred over six months at the UANL Hospital in Monterrey, Mexico. A case-control study was conducted among 189 individuals with active pulmonary TB (97 cases), and latent TB infection (92 controls). Data were collected from interviews, mouthwash samples, and medical chart reviews. Cases and controls were similar in distributions of sex, indigenous ethnicity, marital status, and prevalence of chronic conditions. Cases had a significantly lower socioeconomic status, despite recruitment from similar populations. Smoking was higher among cases than controls (13.8 vs. 3.9 average pack years; p=0.01), as was diabetes (29.9% vs. 8.7%) and alcoholism (13.4% vs. 1.1%). Proportions of genetic ancestry (measured by ancestry informative markers) are pending, but will be added to final regression models, along with significant contextual factors. This project will elucidate the interactions of genetic and socio·cultuml correlates of active TB in an urban Mexican population.
Crews, Dr. Douglas Earl, Ohio State U., Columbus, OH - To aid conference on 'Evolution Theory, Life History, and Human Longevity,' 2009, Ohio State U.
'Evolution Theory, Life History, and Human Longevity'
February 5-7, 2009, Ohio State University, Columbus, Ohio
Organizer: Douglas E. Crews (Ohio State University)
This conference brought together a diverse group of researchers, representing anthropology, medicine and biology, to link their research programs into the broad theme of human life history (LH) evolution. The multi-disciplinary perspective was crucial to examining how LH characteristics link diverse species such as fruit flies and rodents to primate and human
LH evolution. Crosscutting anthropological, biocultural, biomedical, and gerontological interests, this conference focused upon similarities of systems in biology and LH. Papers addressing such issues as reproductive costs, evolutionary pressures, and longevity in fruit flies and humans set the stage for an interdisciplinary exchange of concepts and methodologies. Reports on LH of non-human primates and among fossil hominins explored how modern human life histories and longevities may have developed. Concluding papers examined how modern humans senesce and experience frailty and late-life due to
biocultural forces acting over a 70+-year lifespan. This integrative conference ranged from senescent alterations in fruit flies to the trade-offs encountered by humans as they have evolved.
Gettler, Lee Thomas, Northwestern U., Evanston, IL - To aid research on 'Longitudinal Perspectives on Paternal Socioendocrinology in the Philippines,' supervised by Dr. Christopher Kuzawa
LEE T. GETTLER, then a student at Northwestern University, Evanston, Illinois, was awarded funding in May 2010 to aid research on 'Longitudinal Perspectives on Paternal Socioendocriniology in the Philippines,' supervised by Dr. Christopher Kuzawa. Much prior research has been conducted on the neuroendocrine underpinnings of maternal care, but much less is known about paternal socioendocrinology, particularly among human males. This research is the first to demonstrate that fatherhood causally decreases testosterone in human males. The finding that fathers involved in high levels of childcare have lower testosterone also adds to the growing body of evidence suggesting that suppression of testosterone by fatherhood is potentially mediated through paternal care. Finally, these data represent one of the few evaluations of human paternal prolactin, especially in the context of short-term, father-child interaction. Prolactin is likely an important hormone influencing expression of paternal care behaviors in men, but it has been given substantially less attention in studies of male socioendocrinology, relative to, for example, testosterone. The findings that first-time fathers and those who feel support by their wives show greater declines in prolactin when interacting with their children provide important insights on the plasticity of human male physiology as men move through different life history stages and priorities shift. In total, this research presents multiple lines of evidence that behavior/personality influence biology and vice versa, reflecting the mutually-regulatory, interactive relationship between behavior and biology.
Gettler, Lee T., Sonny S. Agustin, and Christopher W. Kuzawa. 2010. Testosterone, Physical Activity, and Somatic Outcomes Among Filipino Males. American Journal of Physical Anthropology 142(4):590-599.
Gettler, Lee T., Thomas W. McDade, Sonny S. Agustin, and Christopher W. Kuzawa. 2011. Short-Term Changes in Fathers' Hormones during Father-Child Play: Impacts of Paternal Attitudes and Experience. Hormones and Behavior 60(5):599-606.
Gettler, Lee T., Thomas W. McDade, Alan B. Feranil, and Christopher W. Kuzawa. 2011. Longitudinal Evidence that Fatherhood Decreases Testosterone in Human Males. Proceedings of the National Academy of Science, USA 108(39):16194-16199.
Gettler, Lee T., Thomas W. McDade, Alan B. Feranil, and Christopher W. Kuzawa. 2012. Prolactin, Fatherhood, and Reproductive Behavior in Human Males. American Journal of Physical Anthropology 148(3):362-370.
Gettler, Lee T., James J. McKenna, Thomas W. McDade, et al. 2012. Does Cosleeping Contribute to Lower Testosterone Levels in Fathers? Evidence from the Philippines. PLOS One 7(9):1-11,
Lee, Sarah E., U. of Georgia, Athens, GA - To aid research on 'Nutritional and Health Consequences of Children's Self-Provisioning Activity in Xalapa, Mexico,' supervised by Dr. Alexandra A. Brewis
SARAH E. LEE, then a student at the University of Georgia, Athens, Georgia, received funding in September 2003 to aid research on 'Nutritional and Health Consequences of Children's Self-Provisioning Activity in Xalapa, Mexico,' supervised by Dr. Alexandra A. Brewis. This dissertation explores how children's own provisioning activities might influence their well-being under conditions of extreme urban poverty. The immediate purpose of this study was to determine whether self-provisioning children had a measurably different nutrition and health status than children living under the same circumstances who do not engage in provisioning activities (such as working, begging or foraging for food). This dissertation research was conducted in ten neighborhoods in the shantytowns surrounding the city of Xalapa, Veracruz, Mexico from October 2003 until December 2004. The researcher collected a sample size of 95 children between the ages of 8 and 12 who lived with their families. Six different data sets were collected, including 95 household interviews, 285 separate interviews concerning children's time allocation, diet, and illness. The researcher conducted 1425 hours of observation (fifteen hours per child), which provides very rich and accurate data concerning the time allocation and dietary habits of provisioning and non-provisioning children. On-going analysis indicates that the data will support the research question. There does seem to be an age and gender dimension in provisioning actives. Children shared their resources with their siblings, which is a benefit to the siblings, but also shared resources within peer groups. Children who engage in provisioning activities do seem at least marginally healthier, and some are taller than their counterparts who do not engage in provisioning activities. It is likely that the final analysis will show that children who work, beg, or forage for food, will have benefited from their activities.
Quinn, Dr. Elizabeth Anne, Washington U., St. Louis, MO - To aid research on 'Milk with Altitude: Investigations Into Milk Composition and Physiology Among Tibetans'
DR. ELIZABETH A. QUINN, Washington University, St. Louis, Missouri, received funding in April 2013 to aid research on 'Milk with Altitude: Investigations into Milk Composition and Physiology among Tibetans.' This project was designed to specifically investigate the hypotheses that altitude would have an effect on milk composition among high altitude adapted ethnic Tibetans living in Nepal. Milk samples were collected from 130 mothers, with detailed anthropometrics collected on both mothers and infants. As predicted, there was no association between altitude and milk macronutrients or energy, although milk fat was much higher than reported by previous studies. Milk adiponectin did show a dose dependent association with altitude but not maternal body composition, while maternal body fat predicted milk leptin content. Older infants and toddlers in Nubri had significantly lower weight for age z-scores compared to toddlers in Kathmandu (-1.85 vs. -0.36). There were no associations between milk leptin or adiponectin and infant weight for age z-score in Nubri, but both leptin and adiponectin were inversely associated with weight for age z-score in Kathmandu. It appears that the ecological pressures of altitude (hypoxia, marginal nutrition, thermal stress, radiation stress) may have significantly stronger influences on infant weight among high altitude living populations than hormonal signals in milk. In Kathmandu, with many of these external stressors removed, the associations between these hormones and weight for age are present.
Crews, Dr. Douglas Earl, Ohio State U., Columbus, OH - To aid research on 'Frailty and Allostatic Load among Aging Japanese'
DR. DOUGLAS EARL CREWS, Ohio State University, Columbus, Ohio, was awarded a grant in May 2008, to aid research on 'Frailty and Allostatic Load among Aging Japanese.' Residents of Sakiyama City were chosen for this study of how allostatic load and frailty are related to health and morbidity among elderly residents of a more traditional and isolated community. The study obtained sufficient data to examine allostatic load and frailty as correlates of morbidity, physiological function, fertility and aging in elderly Japanese samples living more traditional and less traditional life styles within Sakiyama City. Detailing cross-cultural variation in allostatic load and frailty enhances our interpretations of how biological aspects of senescence may structure health at the latest ages of human life. Determining allostatic load and frailty in an age-stratified sample of Japanese elders also aids in resolving the female-male health paradox, wherein elderly women frequently report poorer health than same-aged men, while same-age men suffer higher mortality. These data allow us to determine whether fertility significantly burdens women's health outcomes. By working directly with physicians engaged in providing health care to participants, the benefits of ongoing research on biomarkers of stress, function, and somatic abilities to clinical interventions and health main